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Good for you, Good for your body
Protect Cognitive Function
Cognitive health is top of mind, not only as you age, but any time you long for improved focus, clarity and energy. While experts agree a healthy diet and lifestyle are the most important components of supporting brain health, research suggests supplements can help fill important nutrient gaps in a our diet. Certain substances like TMG, L-theanine, Spermidine, Resveratrol and Vitamins B support healthy brain function and may protect against memory loss, cognitive decline and neurodegenerative diseases.
Increase Energy Metabolism
Trillions of human cells rely on NAD to perform hundreds of metabolic functions. NAD+ (nicotinamide adenine dinucleotide) is a compound found in every cell in your body and involved in many critical processes, including energy metabolism (turning nutrients into cellular energy) and DNA repair. As we age, the amount of NAD+ decreases and cellular performance decreases. Studies confirm that substances like Nicotinamide Mono and NR, have the ability to elevate level of NAD+ and help mitigate the decline.
Slow Aging
With every birthday, your cells also age. And the older your cells get, the more they’re at risk for becoming damaged. Your telomeres (protective caps at the ends of your chromosomes) shorten. You accumulate zombie cells which increase the chronic inflammation tied to age-related diseases like Alzheimer’s, heart disease, and cancer. Certain anti-aging supplements like Fisetin, Quercetin, Trans-Resveratol, Astragalus, EGCG help combat inflammation and cellular aging to keep you as biologically young as possible.
Reduce Oxidative Stress
Oxidative stress can damage cells, proteins, and DNA, which can contribute to aging. It may also play a role in development of a range of health conditions, including diabetes, cancer, and neurodegenerative diseases such as Alzheimer’s. During oxidative stress, excess free radicals can damage structures inside brain cells and even cause cell death, which may increase the risk of Parkinson’s disease. Certain supplements like Astragalus, Quercetin, Trans-resveratrol help combat against oxydative stress.
Compounds
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Nicotinamide DUO™
400mg Mono + 100mg Riboside
Nicotinamide DUO™ from Perpetua.Life® Biotech is an 80/20 blend of Mono/Riboside, which has been found to boost NAD+ level even higher than Riboside alone. NAD+ is essential for energy metabolism, DNA repair, and gene expression [study1, study2]. NAD+ levels decline with age, linked to physical decline and age-related diseases like Alzheimer’s. Studies show supplementing with NAD+ precursors restores NAD+ levels and prevents age-related decline [study]
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Fisetin
100mg (from Japanese Wax Tree)
Fisetin, a flavonoid compound, acts as a senotherapeutic, eliminating senescent "zombie" cells. It targets growth signaling pathways and plays a significant role in Chronic Diseases [study]. Fisetin shows potential as an anticancer agent, offering cancer prevention and pharmacotherapy [study]. Studies in rodents suggest it reduces senescent cell numbers and extends lifespan [study]. Additionally, Fisetin serves as a dietary antioxidant for promoting health [study]
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Quercetin
250mg (from Sophora japonica)
Quercetin, a flavonoid found in plants and red wine, has antioxidant and anti-inflammatory effects. It may combat cancer cells, control blood sugar, and aid heart health. With potential chemo-preventive properties, it shows promise in cancer prevention and therapy [study]. Quercetin also influences circadian clock genes and aging-related genes [source].
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Trans-Resveratrol
150mg (from Japanese Knotweed)
Trans-Resveratrol, a polyphenol in grapes, berries, and red wine, activates sirtuin genes, promoting longevity. It improves oxidative stress, kidney health, and prevents periodontitis. Also, it regulates circadian clock and aging-related genes[source].
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Astragalus
150mg (from Astragalus membranaceus)
Astragalus, a traditional Chinese herb, combats aging by reducing oxidative stress and boosting immune function. It activates the PI3K/AKT/mTOR pathway, promoting cellular autophagy. Astragalus also shows promise in protecting against inflammation and gastrointestinal cancers. Moreover, it holds potential as a telomerase activator for anti-aging therapies [source].
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Epigallocatechin Gallate (EGCG)
100mg (from Camelliea sinesis)
EGCG, abundant in green tea, has diverse health benefits, including reducing cancer and heart disease risk. It promotes longevity by restoring mitochondria, activating AMPK, and inducing cellular autophagy. EGCG intake is linked to reduced all-cause mortality, diabetes, stroke, and heart disease-related death risk. Animal studies suggest protection against UV-induced skin aging [source 1, source 2, source 3].
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Trimethylglycine
85mg (as Betaine Anhyrous)
TMG effectively controls blood homocysteine levels, associated with heart disease and stroke. It may reduce cancer deaths, protect against lung cancer, and improve memory and brain function in seniors. TMG is also being studied as a potential treatment for neurological disorders like Alzheimer's [source].
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L-Theanine
100mg
L-theanine, an amino acid in teas and mushrooms, may protect against mental decline and extend roundworms' lifespan by around 5%. It shows promise in attenuating liver aging, reducing inflammation, and acting as a neuroprotective agent. L-theanine also prevents long-term side effects of adolescent THC exposure [source].
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Spermidine
10mg (as Spermidine Trihydrochloride)
Spermidine possesses anti-inflammatory and antioxidant properties, enhances respiration and metabolic function, and may reduce the risk of cancer, metabolic disease, heart disease, and neurodegeneration. Additionally, it improves memory and slows cognitive decline by clearing Alzheimer's-related amyloid-beta plaques through autophagy, making it potentially beneficial for older individuals with mild dementia [source].
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Piperine
10mg (from Piper Nigrum)
The primary value of piperine in health supplements is its ability to enhance the bioavailability of some other vitamins and minerals. This mechanism is still being studied, but piperine is known to inhibit the enzymes P-glycoprotein and CYP3A4 in humans. These enzymes are involved in the metabolism and transport of various metabolites. Animal studies also show that piperine inhibits CYP 450 enzymes that metabolize many drugs. In particular, piperine may increase the bioavailability of curcumin by a factor of 20.
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Vitamins B (B2, B6, B12)
B2 - 1mg || B6 - 5mg || B12 - 250mcg
As the building blocks of a healthy body, B vitamins have a direct impact on your energy levels, brain function, and cell metabolism. B vitamins may help prevent infections and help support or promote energy levels (B2), eyesight (B2), proper nerve function (B2, B6), cell health (B6), growth of red blood cells (B6, B12), brain function (B2), cardiovascular health (B6, B12), muscle growth & recovery (B6, B12)
